Organic arsenic compound



JOHANN HUISMANN AND J'URGEN CALLSEN, 0F LEVERKUSEN, NEAR COLOGNE, AND

WILHELM GRU'ITEFIEN, OF ELBERFELD, GERIVIANY, ASSIGNORS T0 FARBEN- FABBIKEN VOBM. FRIEDR. BAYER AND 00., OF LEVERK'USEN, NEAR- COLOGNE,

1 GERMANY.

1N0 Drawing.

To all whom it may concern Be it known that we, JoH'ANN HiJisMANn, JiiuonN CALLSEN, and lViLnninu' Gnt'ir'rn- FIEN, citizens of "Gfimany, residing at, respectively. Leverkusen, near Cologne, and Elbert'cld, Germany, have invented new and useful improvements in Organic Arsenic tompounds, of-whi'ch the following is a specification.

This invention relates to a new organic arsinic compound having most probably the following formula:

I i on S OH O CHMJQOH inn by intramuscular injections'or for in- Elli ternal use. It may also be used for animals.

In order to illustrate our more fully the following example is given, the parts being by'weight:198 parts of I arsenicoxidr is t) aredissolved in 330 parts oi. sodium hydroxid and 700 parts of water. Subsequently 273.5 parts of chloro-acetic acid ('l-(7l-l -(()()ll are dissolved in 'a cold solution of 130 parts of NaOH in 130 parts of water. The latter solution is then added whilst stirring to the solution of arsenic. After the reaction is complete the mixture is neutralized with acetic acid and rendered alkalin with a surplus of ammonia. By the addition of calcium cblorid the calcium salt of the acetic arsinic acid is precipitated, filteredoff and dried:

120 parts of this calcium salt are heated on the water bath together with 1500 parts of normal sulturic acid, the sulfate of calcium is filtered oil and the filtrate is evapo- DBlIV PIOCGSS v ORGANIC ARSENIC COMPOUND.

Application filed September 27, 1921. Serial No. 503,587.

rated in vacuo at 70-80 C. The raw acetic arsinic acid thus obtained is stirred up with acetone, filtered off and dried. It is then further purified by dissolving it in 5 parts of hot alcohol, cooling,'fil tei'i1ig and cvaporating to a small portion in vacuo at about 50-60 C. By the addition of benzene the new product is obtained. It crystallizes from 10 parts of glacial acetic acid in the shape of hard colorless crystals melting at 5% 152 C. It has most probably the formula:

benzene and ether. easily soluble-in water and in alcohol; forming salts with metals which salts retain the valuable therapeutic properties oi the free acid, substantially as described.

In testimony whereof we have hereunto set our hands in the presence of two subscribing witnesses.

.l()l li-\NN llUlSli IANN. [1,. s.] .lllRGEN (,LLLLSEN. [1,. WILI IELM GRllT'lEFllCN. [1,. s.]

llitnesses llans Bini'rnmai, lununnn lvnnoonz. 

